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One Piece. The deformations of faces pushed to the limits Looney Tunes-style are probably the most prominent factor. Luffy's Gum-Gum Fruit powers are a close second, looking like something taken out of a Tex Avery cartoon. It's even been speculated that its lack of similarity to the archetypal style of anime is a factor in why it took so long to catch on outside of Japan.
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